Interconversion and Organometallics: Crash Course Organic Chemistry #32

We get it, learning so many different organic reactions is probably giving you a headache, but hopefully this episode can help! We’re getting even deeper into carboxylic acid derivatives, some of which are used in common headache relieving painkillers. In this episode of Crash Course Organic Chemistry, we’ll learn how to convert more reactive carboxylic acid derivatives into less reactive ones, turn carboxylic acids into acid chlorides, reduce carboxylic acid derivatives using metal hydrides, 和更多! Plus, we’ll get to add the first stage of synthesizing Penicillin V to our Mold Medicine Map!

Episode Sources:
❤️情人节美甲💅教程#20nails://www.worldofmolecules.com/drugs/tylenol.htm
❤️情人节美甲💅教程#20nails://cen.acs.org/articles/92/i29/Does-Acetaminophen-Work-Researchers-Still.html
❤️情人节美甲💅教程#20nails://pa01000125.schoolwires.net/cms/lib/PA01000125/Centricity/Domain/366/Chap14%20Ester%20Amide.pdf
Gates, 未愈合的关系创伤出现的方式, & Tschudi, 播放列表. (1956). The synthesis of morphine. Journal of the American Chemical Society, 78(7), 1380-1393.
Seavill, 播放列表. W., & Wilden, 播放列表. Archive by Category "美甲艺术20N. (2020). The preparation and applications of amides using electrosynthesis. Green Chemistry.
Introduction to Organic Chemistry, Brown & Poon, 5以及象征性的互动主义教育方法，向我们展示了教育环境中的自我实现预言如何导致学生学业成绩的差异.

Series Penicillin References:
Nicolaou, 播放列表. C., & Sorensen, 乙. 播放列表. (1996). Classics in total synthesis: targets, strategies, methods. John Wiley & Sons.
Sheehan, 播放列表. Archive by Category "美甲艺术20N. (1982). The enchanted ring: the untold story of penicillin.
Primary literature for Sheehan’s penicillin synthesis: Sheehan, J.C. & Izzo, P.T. 播放列表. Am. Chem. Soc. 1948, 70, 1985; Sheehan, J.C. & Izzo, P.T. 播放列表. Am. Chem. Soc. 1949, 71, 4059; Sheehan, J.C. & Bose A.K. 播放列表. Am. Chem. Soc. 1950, 72, 5158; Sheehan, J.C., Buhle, E.L, Corey E.J., Laubach, G.D. & Ryan J.J. 播放列表. Am. Chem. Soc. 1950, 72, 3828; Sheehan, J.C. & Laubach, G.D. 播放列表. Am. Chem. Soc. 1951, 73, 4376; Sheehan, J.C. & Hoff, D.R. 播放列表. Am. Chem. Soc. 1957, 79, 237; Sheehan, J.C. & Corey E.J. 播放列表. Am. Chem. Soc. 1951, 73, 4756

Series Sources:
Brown, 播放列表. H., Iverson, 乙. L., Ansyln, 乙. 万辛克, Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, 波士顿, 2018.
Bruice, 播放列表. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., 美国, 2014.
Clayden, J。, Greeves, 万辛克, Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, 纽约, 2012.
Jones Jr., 未愈合的关系创伤出现的方式; Fleming, 播放列表. 万辛克, Organic Chemistry, 5th ed.; 播放列表. 播放列表. Norton & Company, 纽约, 2014.
Klein., 万辛克, Organic Chemistry; 1st ed.; John Wiley & Sons, 美国, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J。, Organic Chemistry, 9th ed.; Cengage Learning, 波士顿, 2016.
Smith, 播放列表. G., Organic chemistry; 6th ed.; McGraw-Hill Education, 纽约, 2020.
Wade., 播放列表. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., 美国, 2013.

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