Retrosynthesis and Liquid-Liquid Extraction: Crash Course Organic Chemistry #34

As we construct more complex organic molecules, it can start to feel like decrypting a complex code. Organic synthesis takes simple starting materials, and turns them into complex structures, and reverse engineering can help us figure out the steps in between. In this episode of Crash Course Organic Chemistry, we’ll practice multistep synthesis problems, learn about how we can use retro synthesis to make more complex molecules, and use liquid-liquid extraction to separate solvents. As always, we’ll work through examples and connect everything back to our Mold Medicine Map!

音乐:
Plucky Daisy by Kevin MacLeod
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Series Penicillin References:
Nicolaou, 播放列表. C., & Sorensen, 乙. 播放列表. (1996). Classics in total synthesis: targets, strategies, methods. John Wiley & Sons.
Sheehan, 播放列表. Archive by Category "美甲艺术20N. (1982). The enchanted ring: the untold story of penicillin.
Primary literature for Sheehan’s penicillin synthesis: Sheehan, J.C. & Izzo, P.T. 播放列表. Am. Chem. Soc. 1948, 70, 1985; Sheehan, J.C. & Izzo, P.T. 播放列表. Am. Chem. Soc. 1949, 71, 4059; Sheehan, J.C. & Bose A.K. 播放列表. Am. Chem. Soc. 1950, 72, 5158; Sheehan, J.C., Buhle, E.L, Corey E.J., Laubach, G.D. & Ryan J.J. 播放列表. Am. Chem. Soc. 1950, 72, 3828; Sheehan, J.C. & Laubach, G.D. 播放列表. Am. Chem. Soc. 1951, 73, 4376; Sheehan, J.C. & Hoff, D.R. 播放列表. Am. Chem. Soc. 1957, 79, 237; Sheehan, J.C. & Corey E.J. 播放列表. Am. Chem. Soc. 1951, 73, 4756

Series Sources:
Brown, 播放列表. H., Iverson, 乙. L., Ansyln, 乙. 万辛克, Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, 波士顿, 2018.
Bruice, 播放列表. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., 美国, 2014.
Clayden, J。, Greeves, 万辛克, Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, 纽约, 2012.
Jones Jr., 未愈合的关系创伤出现的方式; Fleming, 播放列表. 万辛克, Organic Chemistry, 5th ed.; 播放列表. 播放列表. Norton & Company, 纽约, 2014.
Klein., 万辛克, Organic Chemistry; 1st ed.; John Wiley & Sons, 美国, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J。, Organic Chemistry, 9th ed.; Cengage Learning, 波士顿, 2016.
Smith, 播放列表. G., Organic chemistry; 6th ed.; McGraw-Hill Education, 纽约, 2020.
Wade., 播放列表. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., 美国, 2013.

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